Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine.
The immunosuppressive drug, mizoribine, has been used to prevent rejection of organ allografts in humans and in animal models. Based on studies in cell lines, mizoribine has been postulated to be an inhibitor of inosine monophosphate (IMP) dehydrogenase (EC1.2.1.14), a pivotal enzyme in the formatio...
محفوظ في:
| الحاوية / القاعدة: | J Clin Invest |
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| المؤلفون الرئيسيون: | , , , , |
| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
American Society for Clinical Investigation
1991
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329885/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1999502/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115101 |
| الوسوم: |
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