Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine.

The immunosuppressive drug, mizoribine, has been used to prevent rejection of organ allografts in humans and in animal models. Based on studies in cell lines, mizoribine has been postulated to be an inhibitor of inosine monophosphate (IMP) dehydrogenase (EC1.2.1.14), a pivotal enzyme in the formatio...

Fuld beskrivelse

Bibliografiske detaljer

Udgivet i:	J Clin Invest
Principais autores:	Turka, L A, Dayton, J, Sinclair, G, Thompson, C B, Mitchell, B S
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Clinical Investigation 1991
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329885/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1999502/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115101
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!