DNA oxidation matters: The HPLC–electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine

Oxidative DNA damage is important in aging and the degenerative diseases of aging such as cancer. Estimates commonly rely on measurements of 8-oxo-2′-deoxyguanosine (oxo(8)dG), an adduct that occurs in DNA and is also excreted in urine after DNA repair. Here we examine difficulties inherent in the a...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Helbock, Harold J., Beckman, Kenneth B., Shigenaga, Mark K., Walter, Patrick B., Woodall, Alan A., Yeo, Helen C., Ames, Bruce N.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1998
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18204/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9419368/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.1.288
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