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Deoxyadenosine triphosphate as a mediator of deoxyguanosine toxicity in cultured T lymphoblasts.

The mechanism by which 2'-deoxyguanosine is toxic for lymphoid cells is relevant both to the severe cellular immune defect of inherited purine nucleoside phosphorylase (PNP) deficiency and to attempts to exploit PNP inhibitors therapeutically. We have studied the cell cycle and biochemical effe...

詳細記述

保存先:
書誌詳細
出版年:J Clin Invest
主要な著者: Mann, G J, Fox, R M
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 1986
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423812/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3490493/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112710
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