Deoxyadenosine triphosphate as a mediator of deoxyguanosine toxicity in cultured T lymphoblasts.

The mechanism by which 2'-deoxyguanosine is toxic for lymphoid cells is relevant both to the severe cellular immune defect of inherited purine nucleoside phosphorylase (PNP) deficiency and to attempts to exploit PNP inhibitors therapeutically. We have studied the cell cycle and biochemical effects o...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Mann, G J, Fox, R M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1986
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423812/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3490493/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112710
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