Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine.

The immunosuppressive drug, mizoribine, has been used to prevent rejection of organ allografts in humans and in animal models. Based on studies in cell lines, mizoribine has been postulated to be an inhibitor of inosine monophosphate (IMP) dehydrogenase (EC1.2.1.14), a pivotal enzyme in the formatio...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Turka, L A, Dayton, J, Sinclair, G, Thompson, C B, Mitchell, B S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329885/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1999502/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115101
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