Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine.

The immunosuppressive drug, mizoribine, has been used to prevent rejection of organ allografts in humans and in animal models. Based on studies in cell lines, mizoribine has been postulated to be an inhibitor of inosine monophosphate (IMP) dehydrogenase (EC1.2.1.14), a pivotal enzyme in the formatio...

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Опубліковано в::	J Clin Invest
Автори:	Turka, L A, Dayton, J, Sinclair, G, Thompson, C B, Mitchell, B S
Формат:	Artigo
Мова:	Inglês
Опубліковано:	American Society for Clinical Investigation 1991
Предмети:	Research Article
Онлайн доступ:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329885/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1999502/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115101
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