PEA-15 potentiates H-Ras mediated epithelial cell transformation through Phospholipase D

The small GTPase H-Ras is a proto-oncogene that activates a variety of different pathways including the extracellular-signal-regulated kinase mitogen-activated protein kinase (ERK/MAPK) pathway. H-Ras is mutated in many human malignancies and these mutations cause the protein to be constitutively ac...

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Huvudupphovsmän: Sulzmaier, Florian J., Valmiki, Mohana K. Gudur, Nelson, Deirdre A., Caliva, Maisel J., Geerts, Dirk, Matter, Michelle L., White, Eileen P., Ramos, Joe W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295902/
https://ncbi.nlm.nih.gov/pubmed/22105357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.514
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