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PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma

ERK and RSK2 drive proliferation and invasion of many cancers. Phosphoprotein Enriched in Astrocytes 15 (PEA15) binds ERK and RSK2 and high PEA15 levels can impair ERK- and RSK2-dependent transcription. PEA15 expression also inversely correlates with cell motility and invasiveness. We therefore test...

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Détails bibliographiques
Auteurs principaux: Gawecka, Joanna E., Geerts, Dirk, Koster, Jan, Caliva, Maisel J., Sulzmaier, Florian J., Opoku-Ansah, John, Wada, Randal K., Bachmann, André S., Ramos, Joe W.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757132/
https://ncbi.nlm.nih.gov/pubmed/22213050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27415
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