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PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma

ERK and RSK2 drive proliferation and invasion of many cancers. Phosphoprotein Enriched in Astrocytes 15 (PEA15) binds ERK and RSK2 and high PEA15 levels can impair ERK- and RSK2-dependent transcription. PEA15 expression also inversely correlates with cell motility and invasiveness. We therefore test...

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Detalhes bibliográficos
Principais autores: Gawecka, Joanna E., Geerts, Dirk, Koster, Jan, Caliva, Maisel J., Sulzmaier, Florian J., Opoku-Ansah, John, Wada, Randal K., Bachmann, André S., Ramos, Joe W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757132/
https://ncbi.nlm.nih.gov/pubmed/22213050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27415
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