The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling

PEA-15 is a death effector domain-containing phosphoprotein that binds ERK and restricts it to the cytoplasm. PEA-15 also binds to FADD and thereby blocks apoptosis induced by death receptors. Abnormal expression of PEA-15 is associated with type II diabetes and some cancers; however, its physiologi...

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Detalhes bibliográficos
Main Authors: Pastorino, Sandra, Renganathan, Hemamalini, Caliva, Maisel J., Filbert, Erin L., Opoku-Ansah, John, Sulzmaier, Florian J., Gawecka, Joanna E., Werlen, Guy, Shaw, Andrey S., Ramos, Joe W.
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2010
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909277/
https://ncbi.nlm.nih.gov/pubmed/20354143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-144295
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