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Design and Synthesis of Novel Small-molecule Inhibitors of the Hypoxia Inducible Factor Pathway
Hypoxia, a reduction in partial oxygen pressure, is a salient property of solid tumors. Hypoxia drives malignant progression and metastasis in tumors and participates in tumor resistance to radio- and chemotherapies. Hypoxia activates the hypoxia-inducible factor (HIF) family of transcription factor...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3292864/ https://ncbi.nlm.nih.gov/pubmed/22032632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201018g |
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