Structure–activity relationship of 2,2-dimethyl-2H-chromene based arylsulfonamide analogs of 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide, a novel small molecule hypoxia inducible factor-1 (HIF-1) pathway inhibitor and anti-cancer agent

We have discovered that 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide, a novel small molecule HIF-1 pathway inhibitor, can antagonize tumor growth in animal models of cancer, but the treatment necessitates its delivery in a formulation, due to poor water solubilit...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Mun, Jiyoung, Jabbar, Adnan Abdul, Devi, Narra Sarojini, Liu, Yuan, Van Meir, Erwin G., Goodman, Mark M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4875777/
https://ncbi.nlm.nih.gov/pubmed/22682301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.04.064
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados