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Hypoxia inducible factor pathway inhibitors as anticancer therapeutics
Hypoxia is a significant feature of solid tumor cancers. Hypoxia leads to a more malignant phenotype that is resistant to chemotherapy and radiation, is more invasive and has greater metastatic potential. Hypoxia activates the hypoxia inducible factor (HIF) pathway, which mediates the biological eff...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3871878/ https://ncbi.nlm.nih.gov/pubmed/23573973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc.13.17 |
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