Sulfonamides as a New Scaffold for Hypoxia Inducible Factor Pathway Inhibitors

Solid tumors generally grow under hypoxic conditions, a pathophysiological change, which activates the expression of genes responsible for malignant, aggressive, and treatment-refractory properties. Hypoxia inducible factor (HIF) is the chief transcription factor regulating hypoxia-driven gene expre...

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Autors principals: Tan, Chalet, de Noronha, Rita, Devi, Narra S., Jabbar, Adnan A., Kaluz, Stefan, Liu, Yuan, Mooring, Suazette Reid, Nicolaou, K.C., Wang, Binghe, Van Meir, Erwin G.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3292863/
https://ncbi.nlm.nih.gov/pubmed/21831638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.06.099
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