Rational design of small molecule inhibitors targeting the Rac GTPase - p67(phox) signaling axis in inflammation

The NADPH oxidase enzyme complex, NOX2, is responsible for reactive oxygen species (ROS) production in neutrophils and has been recognized as a key mediator of inflammation. Here, we have performed rational design and in silico screen to identify a small molecule inhibitor, Phox-I1, targeting the in...

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Bibliografische gegevens
Hoofdauteurs: Bosco, Emily E., Kumar, Sachin, Marchioni, Filippo, Biesiada, Jacek, Kordos, Miroslaw, Szczur, Kathleen, Meller, Jarek, Seibel, William, Mizrahi, Ariel, Pick, Edgar, Filippi, Marie-Dominique, Zheng, Yi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3292765/
https://ncbi.nlm.nih.gov/pubmed/22365606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.12.017
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