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Rational design of small molecule inhibitors targeting the Rac GTPase - p67(phox) signaling axis in inflammation
The NADPH oxidase enzyme complex, NOX2, is responsible for reactive oxygen species (ROS) production in neutrophils and has been recognized as a key mediator of inflammation. Here, we have performed rational design and in silico screen to identify a small molecule inhibitor, Phox-I1, targeting the in...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3292765/ https://ncbi.nlm.nih.gov/pubmed/22365606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.12.017 |
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