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Rational design of small molecule inhibitors targeting the Ras GEF, SOS1
Ras GTPases regulate intracellular signaling involved in cell proliferation. Elevated Ras signaling activity has been associated with human cancers. Ras activation is catalyzed by guanine-nucleotide exchange factors (GEFs), of which SOS1 is a major member that transduces receptor tyrosine kinase sig...
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| Publicado no: | Chem Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4272618/ https://ncbi.nlm.nih.gov/pubmed/25455859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.09.018 |
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