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Amsacrine as a Topoisomerase II Poison: Importance of Drug-DNA Interactions
Amsacrine (m-AMSA) is an anticancer agent that displays activity against refractory acute leukemias as well as Hodgkin’s and non-Hodgkin’s lymphomas. The drug is comprised of an intercalative acridine moiety coupled to a 4’-amino-methanesulfon-m-anisidide head group. m-AMSA is historically significa...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3289736/ https://ncbi.nlm.nih.gov/pubmed/22304499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201159b |
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