Amsacrine as a Topoisomerase II Poison: Importance of Drug-DNA Interactions

Amsacrine (m-AMSA) is an anticancer agent that displays activity against refractory acute leukemias as well as Hodgkin’s and non-Hodgkin’s lymphomas. The drug is comprised of an intercalative acridine moiety coupled to a 4’-amino-methanesulfon-m-anisidide head group. m-AMSA is historically significa...

Full description

Saved in:
Bibliographic Details
Main Authors: Ketron, Adam C., Denny, William A., Graves, David E., Osheroff, Neil
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289736/
https://ncbi.nlm.nih.gov/pubmed/22304499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201159b
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items