Sequence-dependent Variation in the Reactivity of 8-Oxo-7,8-dihydro-2'-deoxyguanosine toward Oxidation

The goal of this study was to define the effect of DNA sequence on the reactivity of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) toward oxidation. To this end, we developed a quadrupole/time-of-flight (QTOF) mass spectrometric method to quantify the reactivity of site-specifically modified ol...

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Detalhes bibliográficos
Main Authors: Lim, Kok Seong, Taghizadeh, Koli, Wishnok, John S., Babu, I. Ramesh, Shafirovich, Vladimir, Geacintov, Nicholas E., Dedon, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288455/
https://ncbi.nlm.nih.gov/pubmed/22103813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200422g
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