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In situ analysis of 8-oxo-7,8-dihydro-2′-deoxyguanosine oxidation reveals sequence- and agent-specific damage spectra
Guanine is a major target for oxidation in DNA, with 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) as a major product. 8-oxodG is itself significantly more susceptible to oxidation than guanine, with the resulting damage consisting of more than 10 different products. This complexity has hampered eff...
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| Hlavní autoři: | , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3503518/ https://ncbi.nlm.nih.gov/pubmed/23057664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja307525h |
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