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Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier

We reported the selective transport of classical 2-amino-4-oxo-6-substituted pyrrolo[2,3-d]pyrimidines with a thienoyl-for-benzoyl-substituted side chain and a 3- (3a) and 4-carbon (3b) bridge. Compound 3a was more potent than 3b against tumor cells; While 3b was completely selective for transport b...

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Dettagli Bibliografici
Autori principali: Wang, Lei, Cherian, Christina, Desmoulin, Sita Kugel, Mitchell-Ryan, Shermaine, Hou, Zhanjun, Matherly, Larry H., Gangjee, Aleem
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288238/
https://ncbi.nlm.nih.gov/pubmed/22243528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201688n
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