Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cells

Estrogen receptor (ER) binds to distal enhancers within the genome and requires additional factors, such as the Forkhead protein FoxA1, for mediating chromatin interactions. We now show that the human Groucho protein, Transducin-like enhancer protein 1 (TLE1), positively assists some ER-chromatin in...

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Détails bibliographiques
Auteurs principaux: Holmes, Kelly A., Hurtado, Antoni, Brown, Gordon D., Launchbury, Rosalind, Ross-Innes, Caryn S., Hadfield, James, Odom, Duncan T., Carroll, Jason S.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2012
Sujets:
Breast Cancer Special Feature
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286936/
https://ncbi.nlm.nih.gov/pubmed/21536917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018863108
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