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BAYESIAN PHASE I/II ADAPTIVELY RANDOMIZED ONCOLOGY TRIALS WITH COMBINED DRUGS

We propose a new integrated phase I/II trial design to identify the most efficacious dose combination that also satisfies certain safety requirements for drug-combination trials. We first take a Bayesian copula-type model for dose finding in phase I. After identifying a set of admissible doses, we i...

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Bibliografiske detaljer
Main Authors: Yuan, Ying, Yin, Guosheng
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286607/
https://ncbi.nlm.nih.gov/pubmed/22375162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1214/10-AOAS433
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