Dexamethasone exposure and asparaginase antibodies affect relapse risk in acute lymphoblastic leukemia

We have previously hypothesized that higher systemic exposure to asparaginase may cause increased exposure to dexamethasone, both critical chemotherapeutic agents for acute lymphoblastic leukemia. Whether interpatient pharmaco-kinetic differences in dexamethasone contribute to relapse risk has never...

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Hlavní autoři: Kawedia, Jitesh D., Liu, Chengcheng, Pei, Deqing, Cheng, Cheng, Fernandez, Christian A., Howard, Scott C., Campana, Dario, Panetta, John C., Bowman, W. Paul, Evans, William E., Pui, Ching-Hon, Relling, Mary V.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2012
Témata:
Clinical Trials and Observations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286344/
https://ncbi.nlm.nih.gov/pubmed/22117041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-381731
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