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Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase
Because of their low asparagine synthetase (ASNS) expression and asparagine biosynthesis, acute lymphoblastic leukemia (ALL) cells are exquisitely sensitive to asparagine depletion. Consequently, asparaginase is a major component of ALL therapy, but the mechanisms regulating the susceptibility of le...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1821067/ https://ncbi.nlm.nih.gov/pubmed/17380207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30235 |
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