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Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase
Because of their low asparagine synthetase (ASNS) expression and asparagine biosynthesis, acute lymphoblastic leukemia (ALL) cells are exquisitely sensitive to asparagine depletion. Consequently, asparaginase is a major component of ALL therapy, but the mechanisms regulating the susceptibility of le...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1821067/ https://ncbi.nlm.nih.gov/pubmed/17380207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30235 |
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