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Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase
Because of their low asparagine synthetase (ASNS) expression and asparagine biosynthesis, acute lymphoblastic leukemia (ALL) cells are exquisitely sensitive to asparagine depletion. Consequently, asparaginase is a major component of ALL therapy, but the mechanisms regulating the susceptibility of le...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1821067/ https://ncbi.nlm.nih.gov/pubmed/17380207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30235 |
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