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Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase

Because of their low asparagine synthetase (ASNS) expression and asparagine biosynthesis, acute lymphoblastic leukemia (ALL) cells are exquisitely sensitive to asparagine depletion. Consequently, asparaginase is a major component of ALL therapy, but the mechanisms regulating the susceptibility of le...

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Main Authors: Iwamoto, Shotaro, Mihara, Keichiro, Downing, James R., Pui, Ching-Hon, Campana, Dario
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1821067/
https://ncbi.nlm.nih.gov/pubmed/17380207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30235
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