Dexamethasone exposure and asparaginase antibodies affect relapse risk in acute lymphoblastic leukemia

We have previously hypothesized that higher systemic exposure to asparaginase may cause increased exposure to dexamethasone, both critical chemotherapeutic agents for acute lymphoblastic leukemia. Whether interpatient pharmaco-kinetic differences in dexamethasone contribute to relapse risk has never...

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Autors principals: Kawedia, Jitesh D., Liu, Chengcheng, Pei, Deqing, Cheng, Cheng, Fernandez, Christian A., Howard, Scott C., Campana, Dario, Panetta, John C., Bowman, W. Paul, Evans, William E., Pui, Ching-Hon, Relling, Mary V.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Clinical Trials and Observations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286344/
https://ncbi.nlm.nih.gov/pubmed/22117041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-381731
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