Dexamethasone exposure and asparaginase antibodies affect relapse risk in acute lymphoblastic leukemia

We have previously hypothesized that higher systemic exposure to asparaginase may cause increased exposure to dexamethasone, both critical chemotherapeutic agents for acute lymphoblastic leukemia. Whether interpatient pharmaco-kinetic differences in dexamethasone contribute to relapse risk has never...

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Detalhes bibliográficos
Main Authors: Kawedia, Jitesh D., Liu, Chengcheng, Pei, Deqing, Cheng, Cheng, Fernandez, Christian A., Howard, Scott C., Campana, Dario, Panetta, John C., Bowman, W. Paul, Evans, William E., Pui, Ching-Hon, Relling, Mary V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286344/
https://ncbi.nlm.nih.gov/pubmed/22117041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-381731
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