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NF-Y is necessary for hematopoietic stem cell proliferation and survival
HSC function depends on the tight control of proliferation and the balance between self-renewal and differentiation. Here, we report that the trimeric transcription factor NF-Y is critical for the survival of cycling, but not quiescent HSCs. With the use of a conditional knockout mouse model, we dem...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Hematology
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3286206/ https://ncbi.nlm.nih.gov/pubmed/22072554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-359406 |
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