TAT-mediated transduction of NF-Ya peptide induces the ex vivo proliferation and engraftment potential of human hematopoietic progenitor cells

Retroviral overexpression of NF-Ya, the regulatory subunit of the transcription factor NF-Y, activates the transcription of multiple genes implicated in hematopoietic stem cell (HSC) self-renewal and differentiation and directs HSCs toward self-renewal. We asked whether TAT-NF-Ya fusion protein coul...

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Autors principals: Domashenko, Alevtina D., Danet-Desnoyers, Gwenn, Aron, Alissa, Carroll, Martin P., Emerson, Stephen G.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2010
Matèries:
Hematopoiesis and Stem Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974580/
https://ncbi.nlm.nih.gov/pubmed/20616221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-273441
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