Bone marrow homing and engraftment of human hematopoietic stem and progenitor cells is mediated by a polarized membrane domain

Manipulation of hematopoietic stem/progenitor cells (HSPCs) ex vivo is of clinical importance for stem cell expansion and gene therapy applications. However, most cultured HSPCs are actively cycling, and show a homing and engraftment defect compared with the predominantly quiescent noncultured HSPCs...

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Detalhes bibliográficos
Main Authors: Larochelle, Andre, Gillette, Jennifer M., Desmond, Ronan, Ichwan, Brian, Cantilena, Amy, Cerf, Alexandra, Barrett, A. John, Wayne, Alan S., Lippincott-Schwartz, Jennifer, Dunbar, Cynthia E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293639/
https://ncbi.nlm.nih.gov/pubmed/22228628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-08-371583
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