Structural Basis for Increased Toxicity of Pathological Aβ(42):Aβ(40) Ratios in Alzheimer Disease

The β-amyloid peptide (Aβ) is directly related to neurotoxicity in Alzheimer disease (AD). The two most abundant alloforms of the peptide co-exist under normal physiological conditions in the brain in an Aβ(42):Aβ(40) ratio of ∼1:9. This ratio is often shifted to a higher percentage of Aβ(42) in bra...

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Main Authors: Pauwels, Kris, Williams, Thomas L., Morris, Kyle L., Jonckheere, Wim, Vandersteen, Annelies, Kelly, Geoff, Schymkowitz, Joost, Rousseau, Frederic, Pastore, Annalisa, Serpell, Louise C., Broersen, Kerensa
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285338/
https://ncbi.nlm.nih.gov/pubmed/22157754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.264473
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