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Cellular Prion Protein Expression Is Not Regulated by the Alzheimer's Amyloid Precursor Protein Intracellular Domain

There is increasing evidence of molecular and cellular links between Alzheimer's disease (AD) and prion diseases. The cellular prion protein, PrP(C), modulates the post-translational processing of the AD amyloid precursor protein (APP), through its inhibition of the β-secretase BACE1, and oligo...

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Autors principals: Lewis, Victoria, Whitehouse, Isobel J., Baybutt, Herbert, Manson, Jean C., Collins, Steven J., Hooper, Nigel M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283671/
https://ncbi.nlm.nih.gov/pubmed/22363722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031754
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