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Cellular Prion Protein Expression Is Not Regulated by the Alzheimer's Amyloid Precursor Protein Intracellular Domain

There is increasing evidence of molecular and cellular links between Alzheimer's disease (AD) and prion diseases. The cellular prion protein, PrP(C), modulates the post-translational processing of the AD amyloid precursor protein (APP), through its inhibition of the β-secretase BACE1, and oligo...

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Autores principales: Lewis, Victoria, Whitehouse, Isobel J., Baybutt, Herbert, Manson, Jean C., Collins, Steven J., Hooper, Nigel M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283671/
https://ncbi.nlm.nih.gov/pubmed/22363722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031754
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