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Comparison of Identical and Functional Igh Alleles Reveals a Nonessential Role for Eμ in Somatic Hypermutation and Class-Switch Recombination
Somatic hypermutation (SHM), coupled with Ag selection, provides a mechanism for generating Abs with high affinity for invading pathogens. Class-switch recombination (CSR) ensures that these Abs attain pathogen-appropriate effector functions. Although the enzyme critical to both processes, activatio...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3280099/ https://ncbi.nlm.nih.gov/pubmed/20937850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902992 |
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