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A role for the IgH intronic enhancer Eμ in enforcing allelic exclusion
The intronic enhancer (Eμ) of the immunoglobulin heavy chain (IgH) locus is critical for V region gene assembly. To determine Eμ's subsequent functions, we created an Igh allele with assembled V(H) gene but with Eμ removed. In mice homozygous for this Eμ-deficient allele, B cell development was...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2626684/ https://ncbi.nlm.nih.gov/pubmed/19114667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20081202 |
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