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Critical roles of the immunoglobulin intronic enhancers in maintaining the sequential rearrangement of IgH and Igk loci

V(D)J recombination of immunoglobulin (Ig) heavy (IgH) and light chain genes occurs sequentially in the pro– and pre–B cells. To identify cis-elements that dictate this order of rearrangement, we replaced the endogenous matrix attachment region/Igk intronic enhancer (MiE(κ)) with its heavy chain cou...

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Bibliografske podrobnosti
Main Authors: Inlay, Matthew A., Lin, Tongxiang, Gao, Heather H., Xu, Yang
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118354/
https://ncbi.nlm.nih.gov/pubmed/16785310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20052310
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