Association between the Igk and Igh loci mediated by the 3’ Igk enhancer induces decontraction of the Igh locus in pre-B cells

V(D)J recombination at Igh and Igk loci takes place sequentially during successive stages in B cell development. Using 3-dimensional DNA fluorescence in situ hybridization (FISH), we identified a lineage- and stage-specific interchromosomal association between these two loci which marks the transiti...

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Detalhes bibliográficos
Main Authors: Hewitt, Susannah L, Farmer, Deborah, Marszalek, Katarzyna, Cadera, Emily, Liang, Hong-Erh, Xu, Yang, Schlissel, Mark S, Skok, Jane A
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583163/
https://ncbi.nlm.nih.gov/pubmed/18297074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni1567
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