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The Ataxia Telangiectasia Mutated and Cyclin D3 Proteins Cooperate to Help Enforce TCRβ and IgH Allelic Exclusion
Coordination of V rearrangements between loci on homologous chromosomes is critical for Ig and TCR allelic exclusion. The Ataxia Telangietasia mutated (ATM) protein kinase promotes DNA repair and activates checkpoints to suppress aberrant Ig and TCR rearrangements. In response to RAG cleavage of Igκ...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4157102/ https://ncbi.nlm.nih.gov/pubmed/25127855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302201 |
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