Human Aldose Reductase Expression Accelerates Atherosclerosis in Diabetic apoE−/− Mice

OBJECTIVE: There are several pathways that mediate the aberrant metabolism of glucose and that might induce greater vascular damage in the setting of diabetes. The polyol pathway mediated by aldose reductase (AR) has been postulated to be one such pathway. However, it has been reported that AR reduc...

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Main Authors: Vedantham, Srinivasan, Noh, HyeLim, Ananthakrishnan, Radha, Son, Ni, Hallam, Kellie, Hu, Yunying, Yu, Shuiquing, Shen, Xiaoping, Rosario, Rosa, Lu, Yan, Ravindranath, Thyyar, Drosatos, Konstantinos, Huggins, Lesley Ann, Schmidt, Ann Marie, Goldberg, Ira J., Ramasamy, Ravichandran
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278231/
https://ncbi.nlm.nih.gov/pubmed/21636809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.226902
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