Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice

Direct evidence that hyperglycemia, rather than concomitant increases in known risk factors, induces atherosclerosis is lacking. Most diabetic mice do not exhibit a higher degree of atherosclerosis unless the development of diabetes is associated with more severe hyperlipidemia. We hypothesized that...

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Bibliographic Details
Main Authors: Vikramadithyan, Reeba K., Hu, Yunying, Noh, Hye-Lim, Liang, Chien-Ping, Hallam, Kellie, Tall, Alan R., Ramasamy, Ravichandran, Goldberg, Ira J.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2005
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190371/
https://ncbi.nlm.nih.gov/pubmed/16127462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24819
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