Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice

Direct evidence that hyperglycemia, rather than concomitant increases in known risk factors, induces atherosclerosis is lacking. Most diabetic mice do not exhibit a higher degree of atherosclerosis unless the development of diabetes is associated with more severe hyperlipidemia. We hypothesized that...

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Bibliografiska uppgifter
Huvudupphovsmän: Vikramadithyan, Reeba K., Hu, Yunying, Noh, Hye-Lim, Liang, Chien-Ping, Hallam, Kellie, Tall, Alan R., Ramasamy, Ravichandran, Goldberg, Ira J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2005
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190371/
https://ncbi.nlm.nih.gov/pubmed/16127462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24819
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