Regulation of Plasma Fructose and Mortality in Mice by the Aldose Reductase Inhibitor Lidorestat

Aldose reductase (AR), an enzyme widely believed to be involved in the aberrant metabolism of glucose and development of diabetic complications, is expressed at low levels in the mouse. We studied whether expression of human AR (hAR), its inhibition with lidorestat, which is an AR inhibitor (ARI), a...

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Detalhes bibliográficos
Main Authors: Noh, Hye-Lim, Hu, Yunying, Park, Tae-Sik, DiCioccio, Thomas, Nichols, Andrew J., Okajima, Kazue, Homma, Shunichi, Goldberg, Ira J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Endocrine and Diabetes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682276/
https://ncbi.nlm.nih.gov/pubmed/18974362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.136283
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