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Human Aldose Reductase Expression Accelerates Atherosclerosis in Diabetic apoE−/− Mice

OBJECTIVE: There are several pathways that mediate the aberrant metabolism of glucose and that might induce greater vascular damage in the setting of diabetes. The polyol pathway mediated by aldose reductase (AR) has been postulated to be one such pathway. However, it has been reported that AR reduc...

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Bibliografische gegevens
Hoofdauteurs: Vedantham, Srinivasan, Noh, HyeLim, Ananthakrishnan, Radha, Son, Ni, Hallam, Kellie, Hu, Yunying, Yu, Shuiquing, Shen, Xiaoping, Rosario, Rosa, Lu, Yan, Ravindranath, Thyyar, Drosatos, Konstantinos, Huggins, Lesley Ann, Schmidt, Ann Marie, Goldberg, Ira J., Ramasamy, Ravichandran
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278231/
https://ncbi.nlm.nih.gov/pubmed/21636809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.226902
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