Human Aldose Reductase Expression Accelerates Atherosclerosis in Diabetic apoE−/− Mice

OBJECTIVE: There are several pathways that mediate the aberrant metabolism of glucose and that might induce greater vascular damage in the setting of diabetes. The polyol pathway mediated by aldose reductase (AR) has been postulated to be one such pathway. However, it has been reported that AR reduc...

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Hauptverfasser: Vedantham, Srinivasan, Noh, HyeLim, Ananthakrishnan, Radha, Son, Ni, Hallam, Kellie, Hu, Yunying, Yu, Shuiquing, Shen, Xiaoping, Rosario, Rosa, Lu, Yan, Ravindranath, Thyyar, Drosatos, Konstantinos, Huggins, Lesley Ann, Schmidt, Ann Marie, Goldberg, Ira J., Ramasamy, Ravichandran
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278231/
https://ncbi.nlm.nih.gov/pubmed/21636809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.226902
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