Aldose Reductase Drives Hyperacetylation of Egr-1 in Hyperglycemia and Consequent Upregulation of Proinflammatory and Prothrombotic Signals

Sustained increases in glucose flux via the aldose reductase (AR) pathway have been linked to diabetic vascular complications. Previous studies revealed that glucose flux via AR mediates endothelial dysfunction and leads to lesional hemorrhage in diabetic human AR (hAR) expressing mice in an apoE(−/...

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Detalhes bibliográficos
Main Authors: Vedantham, Srinivasan, Thiagarajan, Devi, Ananthakrishnan, Radha, Wang, Lingjie, Rosario, Rosa, Zou, Yu Shan, Goldberg, Ira, Yan, Shi Fang, Schmidt, Ann Marie, Ramasamy, Ravichandran
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2014
Assuntos:
Complications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900544/
https://ncbi.nlm.nih.gov/pubmed/24186862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0032
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