Aldose Reductase Drives Hyperacetylation of Egr-1 in Hyperglycemia and Consequent Upregulation of Proinflammatory and Prothrombotic Signals

Sustained increases in glucose flux via the aldose reductase (AR) pathway have been linked to diabetic vascular complications. Previous studies revealed that glucose flux via AR mediates endothelial dysfunction and leads to lesional hemorrhage in diabetic human AR (hAR) expressing mice in an apoE(−/...

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Bibliografische gegevens
Hoofdauteurs: Vedantham, Srinivasan, Thiagarajan, Devi, Ananthakrishnan, Radha, Wang, Lingjie, Rosario, Rosa, Zou, Yu Shan, Goldberg, Ira, Yan, Shi Fang, Schmidt, Ann Marie, Ramasamy, Ravichandran
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Diabetes Association 2014
Onderwerpen:
Complications
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900544/
https://ncbi.nlm.nih.gov/pubmed/24186862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0032
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