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Aldose reductase and cardiovascular diseases, creating human-like diabetic complications in an experimental model

RATIONALE: Hyperglycemia and reduced insulin actions affect many biological processes. One theory is that aberrant metabolism of glucose via several pathways including the polyol pathway causes cellular toxicity. Aldose reductase (AR) is a multifunctional enzyme that reduces aldehydes. Under diabeti...

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Detalhes bibliográficos
Main Authors: Ramasamy, Ravichandran, Goldberg, Ira J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882633/
https://ncbi.nlm.nih.gov/pubmed/20466987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.213447
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