Cardiomyocyte Aldose Reductase Causes Heart Failure and Impairs Recovery from Ischemia

Aldose reductase (AR), an enzyme mediating the first step in the polyol pathway of glucose metabolism, is associated with complications of diabetes mellitus and increased cardiac ischemic injury. We investigated whether deleterious effects of AR are due to its actions specifically in cardiomyocytes....

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Detalhes bibliográficos
Main Authors: Son, Ni-Huiping, Ananthakrishnan, Radha, Yu, Shuiqing, Khan, Raffay S., Jiang, Hongfeng, Ji, Ruiping, Akashi, Hirokazu, Li, Qing, O'Shea, Karen, Homma, Shunichi, Goldberg, Ira J., Ramasamy, Ravichandran
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459912/
https://ncbi.nlm.nih.gov/pubmed/23029549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046549
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