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Cardiomyocyte Aldose Reductase Causes Heart Failure and Impairs Recovery from Ischemia
Aldose reductase (AR), an enzyme mediating the first step in the polyol pathway of glucose metabolism, is associated with complications of diabetes mellitus and increased cardiac ischemic injury. We investigated whether deleterious effects of AR are due to its actions specifically in cardiomyocytes....
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Главные авторы: | , , , , , , , , , , , |
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Формат: | Artigo |
Язык: | Inglês |
Опубликовано: |
Public Library of Science
2012
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Предметы: | |
Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3459912/ https://ncbi.nlm.nih.gov/pubmed/23029549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046549 |
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