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Cardiomyocyte Aldose Reductase Causes Heart Failure and Impairs Recovery from Ischemia

Aldose reductase (AR), an enzyme mediating the first step in the polyol pathway of glucose metabolism, is associated with complications of diabetes mellitus and increased cardiac ischemic injury. We investigated whether deleterious effects of AR are due to its actions specifically in cardiomyocytes....

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Библиографические подробности
Главные авторы: Son, Ni-Huiping, Ananthakrishnan, Radha, Yu, Shuiqing, Khan, Raffay S., Jiang, Hongfeng, Ji, Ruiping, Akashi, Hirokazu, Li, Qing, O'Shea, Karen, Homma, Shunichi, Goldberg, Ira J., Ramasamy, Ravichandran
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459912/
https://ncbi.nlm.nih.gov/pubmed/23029549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046549
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