Aldose reductase modulates acute activation of mesenchymal markers via the β-catenin pathway during cardiac ischemia-reperfusion

Aldose reductase (AR: human, AKR1B1; mouse, AKR1B3), the first enzyme in the polyol pathway, plays a key role in mediating myocardial ischemia/reperfusion (I/R) injury. In earlier studies, using transgenic mice broadly expressing human AKR1B1 to human-relevant levels, mice devoid of Akr1b3, and phar...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Thiagarajan, Devi, O’ Shea, Karen, Sreejit, Gopalkrishna, Ananthakrishnan, Radha, Quadri, Nosirudeen, Li, Qing, Schmidt, Ann Marie, Gabbay, Kenneth, Ramasamy, Ravichandran
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5708684/
https://ncbi.nlm.nih.gov/pubmed/29190815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188981
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