Aldose reductase mediates myocardial ischemia-reperfusion injury in part by opening mitochondrial permeability transition pore

Aldose reductase (AR), a member of the aldo-keto reductase family, has been demonstrated to play a central role in mediating myocardial ischemia-reperfusion (I/R) injury. Recently, using transgenic mice broadly overexpressing human AR (ARTg), we demonstrated that AR is an important component of myoc...

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Auteurs principaux: Ananthakrishnan, Radha, Kaneko, Michiyo, Hwang, Yuying C., Quadri, Nosirudeen, Gomez, Teodoro, Li, Qing, Caspersen, Casper, Ramasamy, Ravichandran
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2009
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643894/
https://ncbi.nlm.nih.gov/pubmed/19060123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01012.2008
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