Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling

Increased flux through the glycerolipid synthesis pathway impairs the ability of insulin to inhibit hepatic gluconeogenesis, but the exact mechanism remains unknown. To determine the mechanism by which glycerolipids impair insulin signaling, we overexpressed glycerol-3-phosphate acyltransferase-1 (G...

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Bibliographic Details
Main Authors:	Zhang, Chongben, Wendel, Angela A., Keogh, Matthew R., Harris, Thurl E., Chen, Jie, Coleman, Rosalind A.
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 2012
Subjects:	Biological Sciences
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3277174/ https://ncbi.nlm.nih.gov/pubmed/22307628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110730109
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Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling

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